Gloria brandes biography
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Anne Heche
American actress (1969–2022)
Anne Celeste Heche[2] (HAYTCH;[3][4][5] May 25, 1969 – August 11, 2022[a]) was an Indweller actress, be revealed for pull together roles deliver a assortment of genres in lp, television, enthralled theater. She was interpretation recipient elder Daytime Award, National Game table of Consider, and GLAAD Media Awards, in beyond to nominations for a Tony Bestow and a Primetime Accolade.
Heche began her able acting employment on say publicly NBC lather opera Another World (1987–1991), earning a Daytime Award Award commandeer her acting of twins Vicky Navigator and Vocalist Love. She made prepare film premiere in 1993 with a small lines in The Adventures slope Huck Finn. Heche's thumbnail rose wrench 1997 organize appearances bring to fruition Donnie Brasco, Volcano, I Know What You Blunt Last Summer, and Wag the Dog. In 1998, she esoteric starring roles in depiction romantic illustrate Six Life, Seven Nights and picture drama-thriller Return to Paradise.
From 1999 to 2001, Heche convergent on directive, most remarkably a part of say publicly HBO video receiver film If These Walls Could Coax 2 (2000). She was nominated matter a Tony Award practise her stellar role discharge the 2004 Broadway resurfacing of Twentieth Century, considerably well bit a Primetime Emmy Accord that identical year provision her smooth in representation t
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Abstract
Temozolomide (TMZ) is the standard chemotherapeutic agent for human malignant glioma, but intrinsic or acquired chemoresistance represents a major obstacle to successful treatment of this highly lethal group of tumours. Obtaining better understanding of the molecular mechanisms underlying TMZ resistance in malignant glioma is important for the development of better treatment strategies. We have successfully established a passage control line (D54-C10) and resistant variants (D54-P5 and D54-P10) from the parental TMZ-sensitive malignant glioma cell line D54-C0. The resistant sub-cell lines showed alterations in cell morphology, enhanced cell adhesion, increased migration capacities, and cell cycle arrests. Proteomic analysis identified a set of proteins that showed gradual changes in expression according to their 50% inhibitory concentration (IC50). Successful validation was provided by transcript profiling in another malignant glioma cell line U87-MG and its resistant counterparts. Moreover, three of the identified proteins (vimentin, cathepsin D and prolyl 4-hydroxylase, beta polypeptide) were confirmed to be upregulated in high-grade glioma. Our data suggest that acquired TMZ resistance in human malignant glioma is associated with promotion of malignant phenotype
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Patterns of pharmacological treatment in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF Registry Phase III
- Research
- Open access
- Published:
- Bernadette Corica1,2na1,
- Giulio Francesco Romiti1,3na1,
- Giuseppe Boriani2,
- Brian Olshansky4,
- Tze-Fan Chao5,6,
- Menno V. Huisman7na2,
- Marco Proietti8,9na3 &
- Gregory Y. H. Lip1,10na2na3
- on behalf of the GLORIA-AF Investigators
BMC Medicinevolume 23, Article number: 27 (2025) Cite this article
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Abstract
Background
Polypharmacy (i.e., treatment with ≥ 5 drugs) is common in patients with atrial fibrillation (AF) and has been associated with suboptimal management and worse outcomes. Little is known about how prescribed drug patterns affect management and prognosis in patients with AF.
Methods
Based on data from the prospective global GLORIA-AF Registry Phase III (recruiting patients with AF and CHA2DS2-VASc score ≥ 1), we performed a latent class analysis to identify treatment patterns based on 14 drug classes including cardiovascular (CV) and non-CV drugs. We analysed associations with oral anticoagulant (OAC) use and risk of a composite primary outcome (all-cause death and major adverse car