Myrna weissman biography of martin luther
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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Authors
Niamh Mullins 1 , JooEun Kang 2 , Adrian I Campos 3 , Jonathan R I Coleman 4 , Alexis C Edwards 5 , Hanga Galfalvy 6 , Daniel F Levey 7 , Adriana Lori 8 , Andrey Shabalin 9 , Anna Starnawska 10 , Mei-Hsin Su 11 , Hunna J Watson 12 , Mark Adams 13 , Swapnil Awasthi 14 , Michael Gandal 15 , Jonathan D Hafferty 13 , Akitoyo Hishimoto 16 , Minsoo Kim 15 , Satoshi Okazaki 17 , Ikuo Otsuka 18 , Stephan Ripke 19 , Erin B Ware 20 , Andrew W Bergen 21 , Wade H Berrettini 22 , Martin Bohus 23 , Harry Brandt 24 , Xiao Chang 25 , Wei J Chen 26 , Hsi-Chung Chen 27 , Steven Crawford 24 , Scott Crow 28 , Emily DiBlasi 9 , Philibert Duriez 29 , Fernando Fernández-Aranda 30 , Manfred M Fichter 31 , Steven Gallinger 32
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Published in final edited form as: J Psychiatr Res. 2016 Mar 15;78:11–23. doi: 10.1016/j.jpsychires.2016.03.001
Abstract
Remission rates for Major Depressive Disorder (MDD) are low and unpredictable for any given antidepressant. No biological or clinical marker has demonstrated sufficient ability to match individuals to efficacious treatment. Biosignatures developed from the systematic exploration of multiple biological markers, which optimize treatment selection for individuals (moderators) and provide early indication of ultimate treatment response (mediators) are needed. The rationale and design of a multi-site, placebo-controlled randomized clinical trial of sertraline examining moderators and mediators of treatment response is described. The target sample is 400 participants with early onset (<30 years) recurrent MDD. Non-responders to an 8-week trial are switched double blind to either bupropion (for sertraline non-responders) or sertraline (for placebo non-responders) for an additional 8 weeks. Clinical moderators include anxious depression, early trauma, gender, melancholic and atypical depression, anger attacks, Axis II disorder, hypersomnia/fatigue, and chronicity of depression. Biological moderator and medi
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